Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians.

Autor:	Irabor DO; Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria., Oluwasola OA; Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ogunbiyi OJ; Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ogun OG; Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Okolo CA; Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Melas M; USC Norris Comprehensive Cancer Center, Los Angeles, CA, U.S.A., Gruber SB; USC Norris Comprehensive Cancer Center, Los Angeles, CA, U.S.A.; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, U.S.A., Shi C; Department of Pathology, Microbiology and Immunology, School of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Comprehensive Cancer Center, Nashville, TN, U.S.A., Raskin L; Division of Epidemiology, School of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Comprehensive Cancer Center, Nashville, TN, U.S.A. leon.raskin@gmail.com.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2017 May; Vol. 37 (5), pp. 2649-2654.
DOI:	10.21873/anticanres.11612
Abstrakt:	Background: Colorectal cancer (CRC) is the fifth most common cancer in Africa, with significant differences in incidence, biology and clinical behavior from other populations. Materials and Methods: We studied prevalence and clinicopathological features of microsatellite instability (MSI) and young onset CRC in 83 archival samples from the University of Ibadan, Nigeria. Results: Nigerian cases of CRC were MSI-high in 43% and MSI-high CRC had significantly lower histological heterogeneity than microsatellite-stable CRC (20% vs. 55% respectively, p=0.046). Presence of signet ring cell differentiation (10-50% of tumor) was significantly higher in younger patients with CRC (<50 years) (odds ratio(OR)=5.93, 95% confidence interval(CI)=1.17-29.95, p=0.038). Poor differentiation (34%), invasive growth (96%), and high prevalence of mucinous (10%) and signet ring cell adenocarcinomas (4%) were among distinct features of Nigerian patients with CRC. Conclusion: MSI-high CRC is more common in West Africa and more detailed molecular and genetic analysis is warranted as CRC incidence and mortality continue to increase in the Sub-Saharan Africa. (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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