Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair.

Autor:	Rowbotham SP; Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Kim CF; Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: carla.kim@childrens.harvard.edu.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2017 May 04; Vol. 169 (4), pp. 563-565.
DOI:	10.1016/j.cell.2017.04.030
Abstrakt:	Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled growth. (Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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