Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) index as a reference criterion of risk for metabolic syndrome (MetS) and low insulin sensitivity in apparently healthy subjects.

Autor:	Baez-Duarte BG; Faculty of Medicine, Benemérita Universidad Autónoma de Puebla (BUAP), Puebla, Pue., Mexico., Zamora-Gínez I; Faculty of Medicine, Benemérita Universidad Autónoma de Puebla (BUAP), Puebla, Pue., Mexico., González-Duarte R; Faculty of Medicine, UNAM, Mexico City, Mexico., Torres-Rasgado E; Faculty of Medicine, Benemérita Universidad Autónoma de Puebla (BUAP), Puebla, Pue., Mexico., Ruiz-Vivanco G; Faculty of Medicine, Benemérita Universidad Autónoma de Puebla (BUAP), Puebla, Pue., Mexico., Pérez-Fuentes R; Faculty of Medicine, Benemérita Universidad Autónoma de Puebla (BUAP), Puebla, Pue., Mexico.; Centro de Investigación Biomédica de Oriente (CIBIOR), IMSS, Atlixco, Puebla, Pue., Mexico., Celis TMRGOD
Jazyk:	angličtina
Zdroj:	Gaceta medica de Mexico [Gac Med Mex] 2017 Mar - Apr; Vol. 153 (2), pp. 152-158.
Abstrakt:	Aim: To evaluate if the TG/HDL-C index can be considered as a reference criterion of MetS and low insulin sensitivity in apparently healthy subjects. Methods: The subjects were Mexican mestizos who resided in Puebla City, Mexico, who were anthropometrically, biochemically, and clinically characterized. The TG/HDL-C index was calculated by dividing triglyceride (TG) levels by HDL-C levels. MetS was diagnosed by the Third Report from the Adult Treatment Panel-National Cholesterol Education Program (ATP-III NCEP) criteria, while insulin sensitivity was evaluated by the Quantitative Insulin sensitivity Check Index (QUICKI). Results: The study included 813 subjects, with an average age of 38.6 ± 12.1 years, of which 564 were women and 249 men. An association was found between high TG/HDL-C index and low insulin sensitivity (Odds ratio [OR]: 4.09; p < 0.01) and with MetS (OR: 15.29; p < 0.01). A correlation was found between the TG/HDL-C index and QUICKI (rho: -0.4989; p < 0.01) and with MetS (rho: 0.6581; p < 0.01). Conclusion: The results indicate that the TG/HDL-C index is associated with low insulin sensitivity and MetS in apparently healthy subjects, suggesting this index as a reference criterion of risk for low insulin sensitivity and MetS.
Databáze:	MEDLINE
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