Breast Cancer Metastasis to the Axillary Lymph Nodes: Are Changes to the Lymph Node "Soil" Localized or Systemic?
| Autor: | Blackburn HL; Chan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA, USA., Ellsworth DL; Chan Soon-Shiong Institute of Molecular Medicine at Windber, Windber, PA, USA., Shriver CD; Clinical Breast Care Project, Murtha Cancer Center, Walter Reed National Military Medical Center and Uniformed Services University, Bethesda, MD, USA., Ellsworth RE; Clinical Breast Care Project, Murtha Cancer Center, Windber, PA, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Breast cancer : basic and clinical research [Breast Cancer (Auckl)] 2017 Feb 10; Vol. 11, pp. 1178223417691246. Date of Electronic Publication: 2017 Feb 10 (Print Publication: 2017). |
| DOI: | 10.1177/1178223417691246 |
| Abstrakt: | Metastasis is a multistep process that is not well understood. Colonization of a secondary organ requires specific molecular alterations of the host microenvironment. To determine the temporal and spatial changes associated with metastatic dissemination to the axillary lymph nodes, gene expression profiles were compared between histologically normal lymph nodes from node-positive patients and tumor-free nodes from node-negative patients. Using a stringent false discovery rate correction (<0.05) for multiple hypothesis testing, we did not detect any differentially expressed genes between the lymph node groups. Thus, the presence of metastatic cells within the lymphatic system does not elicit widespread changes in gene expression through the axillary basin; rather, lymph nodes independently respond to disseminated tumor cells. Competing Interests: DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|