| Autor: |
Khazdouz M; a Department of Nutrition, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran., Mazidi M; b State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology , Chinese Academy of Sciences , Chaoyang, Beijing., Ehsaei MR; c Department of Neurosurgery, Shahid Kamyab Hospital , Mashhad University of Medical Sciences , Mashhad , Iran., Ferns G; d Division of Medical Education, Brighton & Sussex Medical School , University of Brighton , Brighton , United Kingdom., Kengne AP; e Non-Communicable Disease Research Unit , South African Medical Research Council and University of Cape Town , Cape Town , South Africa., Norouzy AR; a Department of Nutrition, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of dietary supplements [J Diet Suppl] 2018 Jan 02; Vol. 15 (1), pp. 1-10. Date of Electronic Publication: 2017 May 03. |
| DOI: |
10.1080/19390211.2017.1304486 |
| Abstrakt: |
To determine the effects of zinc supplementation on clinical outcomes of patients with severe head trauma, this double-blind clinical trial randomly allocated 100 patients with severe head trauma, aged between 18 to 65 years, to receive placebo or 120 mg zinc via a nasogastric tube for 15 days. Plasma zinc and copper, 24-hour urinary zinc excretion, Sequential Organ Failure Assessment (SOFA) were assessed on days 1, 7, and 16. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and white blood cell (WBC) count were measured on days 1 and 16. Glasgow outcome score (GOS), mortality rate on day 28, and length of stay (LOS) were compared between groups. There were no significant differences in baseline data between groups (all p > .05). Mean plasma zinc concentration was significantly higher in the zinc group than the placebo group on day 7 (119.5 vs. 81.7 µg/dl, p < .001) and day 16 (124.1 vs. 101.1 µg/dl, p < .001). The SOFA, GOS, and inflammation factors were significantly better in the zinc-supplemented group by day 16 (all p < .05). The LOS was shorter (52 vs. 65 days, p = .043) and mortality rate on day 28 was borderline lower (17% vs. 22%, p = .507) in zinc versus placebo groups. Zinc supplementation in the study had favorable effects on GOS, SOFA score, and inflammatory markers in patients with severe head injury. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
