Carbon nanotube capsules enhance the in vivo efficacy of cisplatin.

Autor: Guven A; Department of Chemistry and the Smalley-Curly Institute, MS-60, P.O. Box 1892, Rice University, Houston, TX 77251-1892, USA., Villares GJ; Departments of Molecular and Cellular Biology and Radiology, Lester and Sue Smith Breast Center at Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Department of Biology, University of St. Thomas, 3800 Montrose Boulevard, Houston, TX 77006, USA., Hilsenbeck SG; Dan L. Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Lewis A; Departments of Molecular and Cellular Biology and Radiology, Lester and Sue Smith Breast Center at Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Landua JD; Departments of Molecular and Cellular Biology and Radiology, Lester and Sue Smith Breast Center at Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Dobrolecki LE; Departments of Molecular and Cellular Biology and Radiology, Lester and Sue Smith Breast Center at Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Wilson LJ; Department of Chemistry and the Smalley-Curly Institute, MS-60, P.O. Box 1892, Rice University, Houston, TX 77251-1892, USA. Electronic address: durango@rice.edu., Lewis MT; Departments of Molecular and Cellular Biology and Radiology, Lester and Sue Smith Breast Center at Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address: mtlewis@bcm.edu.
Jazyk: angličtina
Zdroj: Acta biomaterialia [Acta Biomater] 2017 Aug; Vol. 58, pp. 466-478. Date of Electronic Publication: 2017 May 02.
DOI: 10.1016/j.actbio.2017.04.035
Abstrakt: Over the past few years, numerous nanotechnology-based drug delivery systems have been developed in an effort to maximize therapeutic effectiveness of conventional drug delivery, while limiting undesirable side effects. Among these, carbon nanotubes (CNTs) are of special interest as potential drug delivery agents due to their numerous unique and advantageous physical and chemical properties. Here, we show in vivo favorable biodistribution and enhanced therapeutic efficacy of cisplatin (CDDP) encapsulated within ultra-short single-walled carbon nanotube capsules (CDDP@US-tubes) using three different human breast cancer xenograft models. In general, the CDDP@US-tubes demonstrated greater efficacy in suppressing tumor growth than free CDDP in both MCF-7 cell line xenograft and BCM-4272 patient-derived xenograft (PDX) models. The CDDP@US-tubes also demonstrated a prolonged circulation time compared to free CDDP which enhanced permeability and retention (EPR) effects resulting in significantly more CDDP accumulation in tumors, as determined by platinum (Pt) analysis via inductively-coupled plasma mass spectrometry (ICP-MS).
Statement of Significance: Over the past decade, drug-loaded nanocarriers have been widely fabricated and studied to enhance tumor specific delivery. Among the diverse classes of nanomaterials, carbon nanotubes (CNTs), or more specifically ultra-short single-walled carbon nanocapsules (US-tubes), have been shown to be a popular, new platform for the delivery of various medical agents for both imaging and therapeutic purposes. Here, for the first time, we have shown that US-tubes can be utilized as a drug delivery platform in vivo to deliver the chemotherapeutic drug, cisplatin (CDDP) as CDDP@US-tubes. The studies have demonstrated the ability of the US-tube platform to promote the delivery of encapsulated CDDP by increasing the accumulation of drug in breast cancer resistance cells, which reveals how CDDP@US-tubes help overcome CDDP resistance.
(Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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