Monte Carlo simulations of a low energy proton beamline for radiobiological experiments.

Autor: Dahle TJ; a Department of Physics and Technology , University of Bergen , Bergen , Norway., Rykkelid AM; b Department of Physics , University of Oslo , Oslo , Norway., Stokkevåg CH; c Department of Oncology and Medical Physics , Haukeland University Hospital , Bergen , Norway., Mairani A; d Centro Nazionale di Adroterapia Oncologica (CNAO Foundation) , Pavia , Italy.; e Heidelberg Ion Beam Therapy Center (HIT) , Heidelberg , Germany., Görgen A; b Department of Physics , University of Oslo , Oslo , Norway., Edin NJ; b Department of Physics , University of Oslo , Oslo , Norway., Rørvik E; a Department of Physics and Technology , University of Bergen , Bergen , Norway., Fjæra LF; a Department of Physics and Technology , University of Bergen , Bergen , Norway.; c Department of Oncology and Medical Physics , Haukeland University Hospital , Bergen , Norway., Malinen E; b Department of Physics , University of Oslo , Oslo , Norway.; f Department of Medical Physics , Oslo University Hospital , Oslo , Norway., Ytre-Hauge KS; a Department of Physics and Technology , University of Bergen , Bergen , Norway.
Jazyk: angličtina
Zdroj: Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2017 Jun; Vol. 56 (6), pp. 779-786. Date of Electronic Publication: 2017 Feb 22.
DOI: 10.1080/0284186X.2017.1289239
Abstrakt: Background: In order to determine the relative biological effectiveness (RBE) of protons with high accuracy, radiobiological experiments with detailed knowledge of the linear energy transfer (LET) are needed. Cell survival data from high LET protons are sparse and experiments with low energy protons to achieve high LET values are therefore required. The aim of this study was to quantify LET distributions from a low energy proton beam by using Monte Carlo (MC) simulations, and to further compare to a proton beam representing a typical minimum energy available at clinical facilities.
Materials and Methods: A Markus ionization chamber and Gafchromic films were employed in dose measurements in the proton beam at Oslo Cyclotron Laboratory. Dose profiles were also calculated using the FLUKA MC code, with the MC beam parameters optimized based on comparisons with the measurements. LET spectra and dose-averaged LET (LET d ) were then estimated in FLUKA, and compared with LET calculated from an 80 MeV proton beam.
Results: The initial proton energy was determined to be 15.5 MeV, with a Gaussian energy distribution of 0.2% full width at half maximum (FWHM) and a Gaussian lateral spread of 2 mm FWHM. The LET d increased with depth, from approximately 5 keV/μm in the entrance to approximately 40 keV/μm in the distal dose fall-off. The LET d values were considerably higher and the LET spectra were much narrower than the corresponding spectra from the 80 MeV beam.
Conclusions: MC simulations accurately modeled the dose distribution from the proton beam and could be used to estimate the LET at any position in the setup. The setup can be used to study the RBE for protons at high LET d , which is not achievable in clinical proton therapy facilities.
Databáze: MEDLINE
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