Reduced estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m 2 ) at first transurethral resection of bladder tumour is a significant predictor of subsequent recurrence and progression.

Autor: Blute ML Jr; Department of Urology, University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA.; University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA., Kucherov V; Department of Urology, University of Rochester, Rochester, NY, USA., Rushmer TJ; University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Damodaran S; Department of Urology, University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA.; University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA., Shi F; Department of Urology, University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA., Abel EJ; Department of Urology, University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA.; University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA., Jarrard DF; Department of Urology, University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA.; University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA., Richards KA; Department of Urology, University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA.; University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA., Messing EM; Department of Urology, University of Rochester, Rochester, NY, USA., Downs TM; Department of Urology, University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA.; University of Wisconsin Carbone Comprehensive Cancer Center, Madison, WI, USA.
Jazyk: angličtina
Zdroj: BJU international [BJU Int] 2017 Sep; Vol. 120 (3), pp. 387-393. Date of Electronic Publication: 2017 Jun 23.
DOI: 10.1111/bju.13904
Abstrakt: Objective: To evaluate if moderate chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 ] is associated with high rates of non-muscle-invasive bladder cancer (NMIBC) recurrence or progression.
Patients and Methods: A multi-institutional database identified patients with serum creatinine values prior to first transurethral resection of bladder tumour (TURBT). The CKD-epidemiology collaboration formula calculated patient eGFR. Cox proportional hazards models evaluated associations with recurrence-free (RFS) and progression-free survival (PFS).
Results: In all, 727 patients were identified with a median (interquartile range [IQR]) patient age of 69.8 (60.1-77.6) years. Data for eGFR were available for 632 patients. During a median (IQR) follow-up of 3.7 (1.5-6.5) years, 400 (55%) patients had recurrence and 145 (19.9%) patients had progression of tumour stage or grade. Moderate or severe CKD was identified in 183 patients according to eGFR. Multivariable analysis identified an eGFR of <60 mL/min/1.73 m 2 (hazard ratio [HR] 1.5, 95% confidence interval [CI]: 1.2-1.9; P = 0.002) as a predictor of tumour recurrence. The 5-year RFS rate was 46% for patients with an eGFR of ≥60 mL/min/1.73 m 2 and 27% for patients with an eGFR of <60 mL/min/1.73 m 2 (P < 0.001). Multivariable analysis showed that an eGFR of <60 mL/min/1.73 m 2 (HR 3.7, 95% CI: 1.75-7.94; P = 0.001) was associated with progression to muscle-invasive disease. The 5-year PFS rate was 83% for patients with an eGFR of ≥60 mL/min/1.73 m 2 and 71% for patients with an eGFR of <60 mL/min/1.73 m 2 (P = 0.01).
Conclusion: Moderate CKD at first TURBT is associated with reduced RFS and PFS. Patients with reduced renal function should be considered for increased surveillance.
(© 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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