Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative.

Autor: Novoselova EA; «NEARMEDIC PLUS» LLC, Aviakonstruktora Mikoyana str. 12, Moscow, 125252, Russia., Riabova OB; A.N. Bach Institute of Biochemestry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, Leninskiy pr. 33-2b, Moscow, 119071, Russia., Leneva IA; I.Mechnikov Research Institute of Vaccines and Sera, Malyj Kazennyj per. 5, Moscow, 105064, Russia., Nesterenko VG; «NEARMEDIC PLUS» LLC, Aviakonstruktora Mikoyana str. 12, Moscow, 125252, Russia., Bolgarin RN; «NEARMEDIC PLUS» LLC, Aviakonstruktora Mikoyana str. 12, Moscow, 125252, Russia., Makarov VA; A.N. Bach Institute of Biochemestry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, Leninskiy pr. 33-2b, Moscow, 119071, Russia.
Jazyk: angličtina
Zdroj: Acta naturae [Acta Naturae] 2017 Jan-Mar; Vol. 9 (1), pp. 105-107.
Abstrakt: A novel compound, 3,3'-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell's surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses.
Databáze: MEDLINE