A meta-analysis of genome-wide association studies of asthma in Puerto Ricans.

Autor:	Yan Q; Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA., Brehm J; Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA., Pino-Yanes M; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.; Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain., Forno E; Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA., Lin J; Dept of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Oh SS; Dept of Medicine, University of California San Francisco, San Francisco, CA, USA., Acosta-Perez E; Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico., Laurie CC; Dept of Biostatistics, University of Washington, Seattle, WA, USA., Cloutier MM; Dept of Pediatrics, University of Connecticut, Farmington, CT, USA., Raby BA; Channing Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Stilp AM; Dept of Biostatistics, University of Washington, Seattle, WA, USA., Sofer T; Dept of Biostatistics, University of Washington, Seattle, WA, USA., Hu D; Dept of Medicine, University of California San Francisco, San Francisco, CA, USA., Huntsman S; Dept of Medicine, University of California San Francisco, San Francisco, CA, USA., Eng CS; Dept of Medicine, University of California San Francisco, San Francisco, CA, USA., Conomos MP; Dept of Biostatistics, University of Washington, Seattle, WA, USA., Rastogi D; Dept of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA., Rice K; Dept of Biostatistics, University of Washington, Seattle, WA, USA., Canino G; Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico., Chen W; Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA., Barr RG; Dept of Epidemiology, Columbia University, New York, NY, USA.; These authors contributed equally to this work., Burchard EG; Dept of Medicine, University of California San Francisco, San Francisco, CA, USA.; Dept of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; These authors contributed equally to this work., Celedón JC; Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA juan.celedon@chp.edu.; These authors contributed equally to this work.
Jazyk:	angličtina
Zdroj:	The European respiratory journal [Eur Respir J] 2017 May 01; Vol. 49 (5). Date of Electronic Publication: 2017 May 01 (Print Publication: 2017).
DOI:	10.1183/13993003.01505-2016
Abstrakt:	Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans.We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II, the Hartford-Puerto Rico Study and the Hispanic Community Health Study. Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans.The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10 -12 ) at IKZF3 Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block as IKZF3 ( e.g. ZPBP2 , ORMDL3 and GSDMB ) were significantly associated with asthma in Puerto Ricans. With regard to results from a meta-analysis in Europeans, we replicated findings for rs2305480 at GSDMB , but not for SNPs in any other genes. On the other hand, we replicated results from a meta-analysis of North American populations for SNPs at IL1RL1 , TSLP and GSDMB but not for IL33 Our findings suggest that common variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans. Competing Interests: Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com (Copyright ©ERS 2017.)
Databáze:	MEDLINE
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