Synthesis of Substituted Cyclopropanecarboxylates via Room Temperature Palladium-Catalyzed α-Arylation of Reformatsky Reagents.
| Autor: | Greszler SN; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N. Waukegan Road, North Chicago, Illinois 60064, United States., Halvorsen GT; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N. Waukegan Road, North Chicago, Illinois 60064, United States., Voight EA; Centralized Lead Optimization - Discovery Chemistry & Technology, AbbVie, Inc. , 1 N. Waukegan Road, North Chicago, Illinois 60064, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2017 May 19; Vol. 19 (10), pp. 2490-2493. Date of Electronic Publication: 2017 May 01. |
| DOI: | 10.1021/acs.orglett.7b00707 |
| Abstrakt: | The room temperature palladium-catalyzed cross-coupling of aromatic and heteroaromatic halides with Reformatsky reagents derived from 1-bromocyclopropanecarboxylates provides an exceptionally mild method for enolate α-arylation. The method is tolerant of a wide range of functionalities and dramatically shortens many of the existing routes to access widely used 1,1-disubstituted cyclopropanecarboxylate derivatives. |
| Databáze: | MEDLINE |
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