Vulnerability of white matter tracts and cognition to the SOD2 polymorphism: A preliminary study of antioxidant defense genes in brain aging.

Autor: Salminen LE; University of Missouri- St. Louis, Department of Psychological Sciences, 1 University Blvd., Stadler Hall, St. Louis, MO 63121, United States. Electronic address: lauren.salminen@loni.usc.edu., Schofield PR; Neuroscience Research Australia, Barker Street Randwick, Sydney NSW 2031, Australia; School of Medical Sciences, University of New South Wales, Sydney NSW 2052, Australia., Pierce KD; School of Medical Sciences, University of New South Wales, Sydney NSW 2052, Australia., Bruce SE; University of Missouri- St. Louis, Department of Psychological Sciences, 1 University Blvd., Stadler Hall, St. Louis, MO 63121, United States., Griffin MG; University of Missouri- St. Louis, Department of Psychological Sciences, 1 University Blvd., Stadler Hall, St. Louis, MO 63121, United States., Tate DF; Missouri Institute of Mental Health, Berkeley, 4633 World Parkway Circle, Berkeley, MO 63134-3115, United States., Cabeen RP; University of Southern California, Keck School of Medicine, Los Angeles, CA 90032, United States., Laidlaw DH; Brown University, Computer Science Department, Providence, RI 02912, United States., Conturo TE; Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, MO 63110, United States., Bolzenius JD; Missouri Institute of Mental Health, Berkeley, 4633 World Parkway Circle, Berkeley, MO 63134-3115, United States., Paul RH; University of Missouri- St. Louis, Department of Psychological Sciences, 1 University Blvd., Stadler Hall, St. Louis, MO 63121, United States; Missouri Institute of Mental Health, Berkeley, 4633 World Parkway Circle, Berkeley, MO 63134-3115, United States.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2017 Jun 30; Vol. 329, pp. 111-119. Date of Electronic Publication: 2017 Apr 27.
DOI: 10.1016/j.bbr.2017.04.041
Abstrakt: Oxidative stress is a key mechanism of the aging process that can cause damage to brain white matter and cognitive functions. Polymorphisms in the superoxide dismutase 2 (SOD2) and catalase (CAT) genes have been associated with abnormalities in antioxidant enzyme activity in the aging brain, suggesting a risk for enhanced oxidative damage to white matter and cognition among older individuals with these genetic variants. The present study compared differences in white matter microstructure and cognition among 96 older adults with and without genetic risk factors of SOD2 (rs4880) and CAT (rs1001179). Results revealed higher radial diffusivity in the anterior thalamic radiation among SOD2 CC genotypes compared to CT/TT genotypes. Further, the CC genotype moderated the relationship between the hippocampal cingulum and processing speed, though this did not survive multiple test correction. The CAT polymorphism was not associated with brain outcomes in this cohort. These results suggest that the CC genotype of SOD2 is an important genetic marker of suboptimal brain aging in healthy individuals.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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