Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study.

Autor: Siersma V; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. Electronic address: siersma@sund.ku.dk., Thorsen H; The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Holstein PE; Department of Dermatology and Venereology and Copenhagen Wound Healing Centre, Bispebjerg University Hospital, Copenhagen, Denmark., Kars M; Division of Endocrinology, Department of Internal Medicine and Research School CAPHRI, Maastricht University Medical Centre, Maastricht, The Netherlands., Apelqvist J; Department of Endocrinology, University of Malmö, Malmö, Sweden., Jude EB; Diabetes Centre, Tameside General Hospital, Ashton-under-Lyne, UK., Piaggesi A; Sezione Dipartimentale Piede Diabetico, Dipartimento di Area Medica, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Bakker K; IDF Consultative Section and International Working Group on the Diabetic Foot, Heemstede, The Netherlands., Edmonds M; Diabetic Department, Kings College Hospital, London, UK., Jirkovská A; Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic., Mauricio D; Department of Endocrinology & Nutrition, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Reike H; Innere Abteilung, Mariannen Hospital, Werl, Germany., Spraul M; Mathias-Spital, Diabetic Department, Rheine, Germany., Uccioli L; Policlinico Tor Vergata, Department of Internal Medicine, Rome, Italy., Urbancic V; Department of Endocrinology, University Medical Centre, Ljubljana, Slovenia., van Acker K; H Familie Ziekenhuis & Centre de Santé des Fagnes, Department of Endocrinology, Rumst & Chimay, Belgium., van Baal J; Department of Surgery, Twenteborg Ziekenhuis, Almelo, The Netherlands., Schaper NC; Division of Endocrinology, Department of Internal Medicine and Research School CAPHRI, Maastricht University Medical Centre, Maastricht, The Netherlands.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2017 Jul; Vol. 31 (7), pp. 1145-1151. Date of Electronic Publication: 2017 Apr 13.
DOI: 10.1016/j.jdiacomp.2017.04.008
Abstrakt: Aims: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment.
Methods: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics.
Results: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly.
Conclusions: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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