Ocular findings in adult subjects with an inactivating mutation in GH releasing hormone receptor gene.

Autor: Faro ACN; Division of Ophthalmology, Federal University of Sergipe, Aracaju, SE, Brazil., Pereira-Gurgel VM; Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, Brazil., Salvatori R; Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: salvator@jhmi.edu., Campos VC; Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, Brazil., Melo GB; Hospital de Olhos de Sergipe, Aracaju, SE, Brazil., Oliveira FT; Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, Brazil., Oliveira-Santos AA; Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, Brazil., Oliveira CRP; Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, Brazil., Pereira FA; Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, Brazil., Hellström A; Sahlgrenska Academy, The Queen Silvia Children's Hospital, Göteborg, Sweden., Oliveira-Neto LA; Division of Dentistry, Federal University of Sergipe, Aracaju, SE, Brazil., Valença EHO; Division of Speech Therapy, Federal University of Sergipe, Aracaju, SE, Brazil., Aguiar-Oliveira MH; Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, Brazil.
Jazyk: angličtina
Zdroj: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society [Growth Horm IGF Res] 2017 Jun; Vol. 34, pp. 8-12. Date of Electronic Publication: 2017 Apr 21.
DOI: 10.1016/j.ghir.2017.04.002
Abstrakt: Objective: Ocular function is fundamental for environmental adaptation and survival capacity. Growth factors are necessary for a mature eyeball, needed for adequate vision. However, the consequences of the deficiency of circulating growth hormone (GH) and its effector insulin-like growth factor I (IGF-I) on the physical aspects of the human eye are still debated. A model of untreated isolated GH deficiency (IGHD), with low but measurable serum GH, may clarify this issue. The aim of this study was to assess the ocular aspects of adult IGHD individuals who have never received GH therapy.
Design: Cross sectional study.
Methods: Setting: University Hospital, Federal University of Sergipe, Brazil.
Patients: Twenty-five adult (13 males, mean age 50.1years, range 26 to 70years old) IGHD subjects homozygous for a null mutation (c.57+1G>A) in the GHRH receptor gene, and 28 (15 males, mean age 51.1years, range 26 to 67years old) controls were submitted to an endocrine and ophthalmological assessment. Forty-six IGHD and 50 control eyes were studied.
Main Outcome Measures: Visual acuity, intraocular pressure, refraction (spherical equivalent), ocular axial length (AL), anterior chamber depth (ACD), lens thickness (LT), vitreous depth (VD), mean corneal curvature (CC) and central corneal thickness (CCT).
Results: IGHD subjects exhibited unmeasurable serum IGF-I levels, similar visual acuity, intraocular pressure and LT, higher values of spherical equivalent and CC, and lower measures of AL, ACD, VD and CCT in comparison to controls, but within their respective normal ranges. While mean stature in IGHD group was 78% of the control group, mean head circumference was 92% and axial AL was 96%.
Conclusions: These observations suggest mild ocular effects in adult subjects with severe IGF-I deficiency due to non-treated IGHD.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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