Inflammation and Immune Activation in Antiretroviral-Treated Human Immunodeficiency Virus Type 1-Infected African Infants and Rotavirus Vaccine Responses.

Autor:	Uprety P; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, Lindsey JC; Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts, USA., Levin MJ; Section of Pediatric Infectious Diseases, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, USA., Rainwater-Lovett K; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Ziemniak C; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Bwakura-Dangarembizix M; Department of Pediatrics and Child Health, University of Zimbabwe College of Health Sciences, Zimbabwe., Kaplan SS; Merck & Co, Inc, Kenilworth, New Jersey, USA., Nelson M; Merck & Co, Inc, Kenilworth, New Jersey, USA., Zadzilka A; Frontier Science and Technology Research Foundation, Amherst, New York, USA., Weinberg A; Section of Pediatric Infectious Diseases, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, USA., Persaud D; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2017 Mar 15; Vol. 215 (6), pp. 928-932.
DOI:	10.1093/infdis/jix060
Abstrakt:	Biomarkers of inflammation and immune activation were correlated with rotavirus vaccine responses in 68 human immunodeficiency virus type 1 (HIV-1)–infected (and 116 HIV-exposed but uninfected (HEU) African infants receiving pentavalent rotavirus vaccine (RV5) in a clinical trial. Prevaccination, HIV-1+ infants had significantly higher concentrations of interferon γ (IFNγ), interleukin1β, interleukin 2, interleukin 6, interleukin 10 (IL-10), and soluble CD14 compared with HEU infants. Postvaccination concentrations of neutralizing antibodies to RV5 were negatively correlated with prevaccination concentrations of IL-10 (RV5 surface proteins G1 and P1) and IFNγ (G1) in the HIV-1+ infants, whereas antirotavirus immunoglobulin A (IgA) levels were not. Heightened inflammation and immune activation in HIV-1+ infants did not alter IgA responses associated with protection from rotavirus disease. (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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