Association of vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients.

Autor:	Cusato J; Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy., Boglione L; Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy., De Nicolò A; Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy., Imbornone R; Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy., Cardellino CS; Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy., Ghisetti V; Laboratory of Microbiology & Virology, Department of Infectious Diseases, Amedeo di Savoia Hospital, Turin, Italy., Carcieri C; Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy., Cariti G; Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy., Di Perri G; Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy., D'Avolio A; Department of Medical Sciences, Unit of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy.
Jazyk:	angličtina
Zdroj:	Pharmacogenomics [Pharmacogenomics] 2017 May; Vol. 18 (7), pp. 651-661. Date of Electronic Publication: 2017 Apr 28.
DOI:	10.2217/pgs-2016-0041
Abstrakt:	Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results:  VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.
Databáze:	MEDLINE
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