| Autor: |
Ghonghadze M; Tbilisi State Medical University, Department of Pharmacotherapy; JSC 'Curatio', Tbilisi, Georgia., Antelava N; Tbilisi State Medical University, Department of Pharmacotherapy; JSC 'Curatio', Tbilisi, Georgia., Liluashvili K; Tbilisi State Medical University, Department of Pharmacotherapy; JSC 'Curatio', Tbilisi, Georgia., Okujava M; Tbilisi State Medical University, Department of Pharmacotherapy; JSC 'Curatio', Tbilisi, Georgia., Pachkoria K; Tbilisi State Medical University, Department of Pharmacotherapy; JSC 'Curatio', Tbilisi, Georgia. |
| Abstrakt: |
Administration of Aacetylsalicylic acid in children with viral infections (influence B, chickenpox) can be related with development of Reye syndrome - severe encephalopathy and liver insufficiency with mortality in 50% of cases. During Reye syndrome most important is deficiency of carnitine and hepatocyte damage. Decreased amount of carnitine impairs the energy function of mitochondria and gluconeogenesis as well as production of urea. As a result develops toxic encephalopathy and liver insufficiency. The goal of the research was assessment of efficacy of L-Carnitine, Corvitin and their combination on functional state of liver in experimental model of Reye Syndrome in rats. The study was performed on mature white male Wistar rates with body mass 150-180g. 50 rats were randomly divided into 5 groups (10 rats in each group). The model of Reye syndrome was induced in accordance with A.Vengersky's method. Intraperitoneal administration of 4-pentenoic acid was performed once daily during seven days, the used dosage was 20mg/kg. The treatment of toxic hepatitis was carried with intraperitoneal administration of L-Carnitine 300mg/kg, Corvitine 100mg/kg and concurrent administration of these drugs. Monotherapy with Corvitin and L-Carnitin successfully improved liver function and equally decreased indicators of hepatocyte's cytolyses and increased levels of glucose and urea. The markers of cholestasis was slightly more improved during use of L-Carnitine. Simultaneous use of both drugs was effective in rats with Reye syndrome, indicators of liver damage normalized and herewith, no mortality outcome was observed. The most pronounced hepatoprotective effect of concurrent administration of L-Carnitine and Corvitin may be due to synergic action of these drugs and such regime can be recommended for correction of liver function during Reye syndrome. |
