| Autor: |
Lee YT; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, P.R. China., Laxton V; Intensive Care Department, Royal Brompton and Harefield NHS Trust, London SW3 6NP, UK., Lin HY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, P.R. China., Chan YWF; School of Biological Sciences, University of Cambridge, Cambridge CB2 1AG, UK., Fitzgerald-Smith S; Faculty of Medicine, University of Bristol, Bristol BS8 1TH, UK., To TLO; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, P.R. China., Yan BP; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, P.R. China.; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia., Liu T; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China., Tse G; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, P.R. China.; Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China. |
| Abstrakt: |
Atherosclerosis is a significant cause of morbidity and mortality globally. Many animal models have been developed to study atherosclerosis, and permit experimental conditions, diet and environmental risk factors to be carefully controlled. Pathophysiological changes can be produced using genetic or pharmacological means to study the harmful consequences of different interventions. Experiments using such models have elucidated its molecular and pathophysiological mechanisms, and provided platforms for pharmacological development. Different models have their own advantages and disadvantages, and can be used to answer different research questions. In the present review article, different species of atherosclerosis models are outlined, with discussions on the practicality of their use for experimentation. |
