[Thymic neuroendocrine tumor: about a case and review of the literature].

Autor: Ramahandrisoa AVN; Faculté de Médecine d'Antananarivo, Madagascar., Hasiniatsy NRE; Faculté de Médecine d'Antananarivo, Madagascar.; Unité d'Oncologie Médicale, Centre Hospitalier de Soavinandriana, Madagascar., Refeno V; Faculté de Médecine d'Antananarivo, Madagascar., Vololonantenaina CR; Unité d'Anatomie Pathologique, Institut Pasteur de Madagascar., Rakotoarisoa AJC; Faculté de Médecine d'Antananarivo, Madagascar.; Service Chirurgie Thoracique, Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona, Madagascar., Rakotovao HJL; Faculté de Médecine d'Antananarivo, Madagascar.; Service Chirurgie Thoracique, Centre Hospitalier Universitaire Joseph Ravoahangy Andrianavalona, Madagascar., Rafaramino F; Faculté de Médecine d'Antananarivo, Madagascar.
Jazyk: francouzština
Zdroj: The Pan African medical journal [Pan Afr Med J] 2017 Jan 18; Vol. 26, pp. 25. Date of Electronic Publication: 2017 Jan 18 (Print Publication: 2017).
DOI: 10.11604/pamj.2017.26.25.11500
Abstrakt: Thymic neuroendocrine tumors (TNET) are rare, with little-known prognosis. This study aims to report a case of TNET and to highlight the diagnostic and therapeutic difficulties in low-resource settings. A 60-year-old man presented with chest pain, greasy cough and recent weight loss. Chest CT scan showed anterior mediastinal tissue mass. Histologic evaluation of a 4 months-biopsy specimen obtained from anterior mediastinotomy showed a well differentiated TNET, labeled intensely positive for chromogranin and synaptophysin. The search for other neuroendocrine tumors and the extent of extension were negative. The tumor was immediately inextricable and radiation therapy was unavailable. The patient underwent two lines of first line chemotherapy. At 16 months follow-up, the patient was asymptomatic but showed tumor progression. The diagnosis of TNET may be delayed when immunohistochemistry is not routinely performed. Chemotherapy is associated with symptoms improvement in palliative care situation.
Competing Interests: Les auteurs déclarent avoir aucun conflit d'intérêts.
Databáze: MEDLINE
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