CD4+ cells recovery in HIV positive patients with severe immunosuppression at HAART initiation at Centre Medico-Social Cor-Unum, Kigali.

Autor:	Merci NM; Mount Kenya University, College of Health Sciences, Department of Medical Laboratory Sciences, Kenya., Emerence U; Mount Kenya University, College of Health Sciences, Department of Medical Laboratory Sciences, Kenya., Augustin N; Mount Kenya University, College of Health Sciences, Department of Medical Laboratory Sciences, Kenya.; University of Rwanda, College of Medicine and health Sciences, Department of Biomedical Laboratory Sciences, Kigali, Rwanda., Habtu M; Mount Kenya University, College of Health Sciences, Department of Medical Laboratory Sciences, Kenya.; Institute of Tropical Medicine and Infectious Diseases, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya., Julie I; Mount Kenya University, College of Health Sciences, Department of Medical Laboratory Sciences, Kenya., Angelique T; Mount Kenya University, College of Health Sciences, Department of Medical Laboratory Sciences, Kenya., Jessica B; Mount Kenya University, College of Health Sciences, Department of Medical Laboratory Sciences, Kenya., Cynthia A; Mount Kenya University, College of Health Sciences, Department of Medical Laboratory Sciences, Kenya., Penda AT; Mount Kenya University, College of Health Sciences, Department of Medical Laboratory Sciences, Kenya.; University of Rwanda, College of Medicine and health Sciences, Department of Biomedical Laboratory Sciences, Kigali, Rwanda.
Jazyk:	angličtina
Zdroj:	The Pan African medical journal [Pan Afr Med J] 2017 Jan 12; Vol. 26, pp. 14. Date of Electronic Publication: 2017 Jan 12 (Print Publication: 2017).
DOI:	10.11604/pamj.2017.26.14.10488
Abstrakt:	Introduction: Up to 30% of HIV infected patients who are receiving HAART do not exhibit a marked increase in the CD4+ T cell count. There is still a concern that immune recovery may not be complete once CD4+ T cells have decreased below 200 cells/μl. The objective is to assess CD4+ cell recovery in HIV+ patients with CD4 count below 200 cells/μl) at HAART initiation. Methods: This was a retrospective cohort study among 110 HIV+ patients with initial CD4 count < 200 cells/μl. Baseline Age, sex, CD4 count and viral load were extracted from the patient's database. After12 months of HAART; CD4 count was done using flow cytometry and viremia by COBAS AmpliPrep/COBAS TaqMan HIV-1 test v 2.0 technology. Results: The mean age of the respondents was 35 years; males being 57% and females were 43%. The mean CD4 count before HAART was 110.18 cells/μl whereas at 12 months of HAART; this was 305.01 cells/μl. Though some patients did not achieve a CD4 count of more than 200 cells/μl or a drop in viral load; there was a significant recovery of CD4+ cells (P value=0.000) and viremia following HAART (P value=0.001). Participants aged 18-30 years were likely to have less than 200 cells/μl CD4 count (46.4%) [OR=4.33; 95%CI: 1.29-14.59; P=0.018] than participants aged above 40 years (16.7%). Conclusion: HAART was associated with viremia suppression but many patients failed to achieve a CD4 count >200 cells/μl. HAART before severe immunosuppression is a key factor for immune restoration among HIV+ patients. Competing Interests: The authors declare no competing interests.
Databáze:	MEDLINE
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