Clinical and microbiological features associated with group B Streptococcus bone and joint infections, France 2004-2014.

Autor: Kernéis S; Université Paris Descartes, Paris, France.; Infectiologie, Hôpitaux Universitaires Paris Centre, Cochin-Broca-Hôtel Dieu, AP-HP, Paris, France., Plainvert C; CNR Streptocoques, Hôpitaux Universitaires Paris Centre, site Cochin, AP-HP, Paris, France.; DHU Risques et Grossesse, AP-HP, Paris, France.; Équipe Barrières et Pathogènes, Institut Cochin, Inserm 1016, CNRS UMR 8104, Paris, France., Barnier JP; CNR Streptocoques, Hôpitaux Universitaires Paris Centre, site Cochin, AP-HP, Paris, France., Tazi A; Université Paris Descartes, Paris, France.; CNR Streptocoques, Hôpitaux Universitaires Paris Centre, site Cochin, AP-HP, Paris, France.; DHU Risques et Grossesse, AP-HP, Paris, France.; Équipe Barrières et Pathogènes, Institut Cochin, Inserm 1016, CNRS UMR 8104, Paris, France., Dmytruk N; CNR Streptocoques, Hôpitaux Universitaires Paris Centre, site Cochin, AP-HP, Paris, France.; DHU Risques et Grossesse, AP-HP, Paris, France., Gislain B; CNR Streptocoques, Hôpitaux Universitaires Paris Centre, site Cochin, AP-HP, Paris, France., Loubinoux J; Université Paris Descartes, Paris, France.; CNR Streptocoques, Hôpitaux Universitaires Paris Centre, site Cochin, AP-HP, Paris, France., El Sayed F; Laboratoire de Microbiologie, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France.; UMR 1173, UFR Simone Veil, Université de Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France., Cattoir V; Service de Microbiologie, CHU de Caen, Caen, France., Desplaces N; Service de Microbiologie, Groupe Hospitalier Diaconesses Croix Saint Simon, Paris, France., Vernet V; Laboratoire de Bactériologie, CHU de Reims, Hôpital Maison Blanche, Reims, France.; Université de Reims Champagne-Ardenne, Faculté de médecine, EA 4687, Reims, France., Morand P; Université Paris Descartes, Paris, France.; CNR Streptocoques, Hôpitaux Universitaires Paris Centre, site Cochin, AP-HP, Paris, France., Poyart C; Université Paris Descartes, Paris, France. claire.poyart@aphp.fr.; CNR Streptocoques, Hôpitaux Universitaires Paris Centre, site Cochin, AP-HP, Paris, France. claire.poyart@aphp.fr.; DHU Risques et Grossesse, AP-HP, Paris, France. claire.poyart@aphp.fr.; Équipe Barrières et Pathogènes, Institut Cochin, Inserm 1016, CNRS UMR 8104, Paris, France. claire.poyart@aphp.fr.
Jazyk: angličtina
Zdroj: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2017 Sep; Vol. 36 (9), pp. 1679-1684. Date of Electronic Publication: 2017 Apr 26.
DOI: 10.1007/s10096-017-2983-y
Abstrakt: This study describes the clinical and microbiological features associated with group B Streptococcus (GBS) bone and joint infections (BJIs). It was a retrospective analysis of adult cases of GBS BJIs reported to the French National Reference Center for Streptococci from January 2004 to December 2014. Clinical data and GBS molecular characteristics are reported. Strains were collected from 163 patients. The most frequent comorbidities were: solid organ cancer (n = 21, 21%) and diabetes mellitus (n = 20, 20%). The main infection sites were knee (47/155 = 30%) and hip (43/155 = 27%), and occurred on orthopedic devices in 71/148 cases (48%). CPS III (n = 47, 29%), Ia (n = 26, 16%) and V (n = 40, 25%) were predominant. Resistance to erythromycin, clindamycin and tetracycline was detected in 55/163 (34%), 35/163 (21%) and 132/163 (81%) strains, respectively. The most frequent sequence types were ST-1 (n = 21, 25%), ST-17 (n = 17, 20%) and ST-23 (n = 11, 13%). The rate of resistance to erythromycin was 0% for ST-17 strains, 52% (n = 11) for ST-1 and 44% (n = 7) for ST-23 (p < 0.001). GBS bone and joint infections predominantly occur in patients aged >50 years and/or with comorbidities such as cancer and diabetes mellitus. CPS type distribution and MLST are very similar to that of other adult GBS invasive infections.
Databáze: MEDLINE
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