Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy - a case report.

Autor: Huong NTC; Department of Infectious Diseases, University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh city, Vietnam. camhuong37@yahoo.com.; The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. camhuong37@yahoo.com., Altibi AMA; Faculty of Medicine, University of Jordan, Amman, Jordan., Hoa NM; Department of Infectious Diseases, University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh city, Vietnam.; The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Tuan LA; Department of Infectious Diseases, University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh city, Vietnam.; The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Salman S; Dermatology and Venereology Department, Tanta University Hospital, Tanta, Egypt., Morsy S; Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt., Lien NTB; Ho Chi Minh City Hospital of Dermatology-Venereology, Ho Chi Minh City, Vietnam., Truong NT; The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Mai NTH; The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Hoa PTL; Department of Infectious Diseases, University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh city, Vietnam.; The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thang NB; Department of Neurology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Trung VT; Department of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam. vanthetrungdhyd@yahoo.com.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2017 Apr 26; Vol. 17 (1), pp. 311. Date of Electronic Publication: 2017 Apr 26.
DOI: 10.1186/s12879-017-2415-8
Abstrakt: Background: Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans and most remarkably manifests in HIV-infected individuals, especially in the settings of very low CD4 count. Development of cryptococcosis in HIV-uninfected individuals is exceedingly rare and usually signifies a marked immunodeficiency. Cryptococcosis in association with myasthenia gravis or thymoma has been previously documented in only very few cases in the literature.
Case Presentation: We reported a complicated case of severe cutaneous cryptococcosis in a 39-year-old Vietnamese male patient with myasthenia gravis on long-term immunosuppressive therapy. The patient presented with a five month history of recurrent and progressive skin lesions that later on progressed into cryptococcal meningitis.
Conclusion: Through this case, we aimed to emphasize the importance of including cutaneous cryptococcosis in the differential diagnosis of cutaneous lesions in patients on chronic immunosuppressive therapy. The cutaneous manifestations of cryptococcosis can be the first clue for a disseminated disease, which makes early recognition crucial and life-saving.
Databáze: MEDLINE
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