Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis.

Autor:	Toussaint-Duyster LC; Department of Orthopedics, Section of Physical Therapy, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands., Wong YYM; Department of Neurology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands., Van der Cammen-van Zijp MH; Department of Orthopedics, Section of Physical Therapy, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands., Van Pelt-Gravesteijn D; Department of Neurology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands., Catsman-Berrevoets CE; Department of Pediatric Neurology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands., Hintzen RQ; Department of Neurology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands., Neuteboom RF; Department of Pediatric Neurology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2018 Jun; Vol. 24 (7), pp. 982-990. Date of Electronic Publication: 2017 Apr 26.
DOI:	10.1177/1352458517706038
Abstrakt:	Background and Objective: Fatigue and physical impairments are a major concern in children with multiple sclerosis (MS) and after acute disseminated encephalomyelitis (post-ADEM). We here aimed to evaluate the interaction between fatigue, exercise capacity, motor performance, neurological status, and quality of life (HRQoL). Methods: In this cross-sectional study, data of 38 children (MS n = 22, post-ADEM n = 16), aged 4-17 years attending our national pediatric MS center, were studied. Fatigue was measured with the Pediatric Quality of Life Multidimensional Fatigue Scale, exercise capacity with the Bruce Protocol, motor performance with the Movement Assessment Battery for Children second edition, HRQoL with the Pediatric Quality of Life Questionnaire, and extent of disability with the Expanded Disability Status Scale (EDSS). Results: Children with MS and post-ADEM experienced more fatigue ( p < 0.001), reduced exercise capacity ( p < 0.001), and impaired motor performance ( p < 0.001), despite low scores on the EDSS. Fatigue, but not the other parameters, was significantly correlated with HRQoL. Fatigue was not correlated with exercise capacity. Conclusion: We confirm the major impact of fatigue on quality of life in children with MS and post-ADEM. Fatigue was not explained by reduced exercise capacity or impaired motor performance. An important finding for clinical practice is that the low EDSS score did not reflect the poor physical functioning.
Databáze:	MEDLINE
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