Immunoglobulin-Based Investigation of Spontaneous Resolution of Chlamydia trachomatis Infection.

Autor:	Bakshi RK; Department of Medicine, University of Alabama at Birmingham., Gupta K; Department of Medicine, University of Alabama at Birmingham., Jordan SJ; Department of Medicine, University of Alabama at Birmingham., Brown LT; Department of Medicine, University of Alabama at Birmingham., Press CG; Department of Medicine, University of Alabama at Birmingham., Gorwitz RJ; Centers for Disease Control and Prevention, Division of STD Prevention, Atlanta, Georgia., Papp JR; Centers for Disease Control and Prevention, Division of STD Prevention, Atlanta, Georgia., Morrison SG; Department of Microbiology and Immunology., Lee JY; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock., Morrison RP; Department of Microbiology and Immunology., Geisler WM; Department of Medicine, University of Alabama at Birmingham.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2017 Jun 01; Vol. 215 (11), pp. 1653-1656.
DOI:	10.1093/infdis/jix194
Abstrakt:	Chlamydia trachomatis elementary body enzyme-linked immunosorbent assay (ELISA) was used to investigate serum anti-CT immunoglobulin G1 (IgG1; long-lived response) and immunoglobulin G3 (IgG3; short-lived response indicating more recent infection) from treatment (enrollment) and 6-month follow-up visits in 77 women previously classified as having spontaneous resolution of chlamydia. Of these women, 71.4% were IgG1+IgG3+, consistent with more recent chlamydia resolution. 15.6% were IgG3- at both visits, suggesting absence of recent chlamydia. Using elementary body ELISA, we demonstrated approximately 1 in 6 women classified as having spontaneous resolution of chlamydia might have been exposed to C. trachomatis but not infected. Further, we classified their possible infection stage. (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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