Virulence potential of Staphylococcus aureus isolates from Buruli ulcer patients.

Autor: Amissah NA; Department of Internal Medicine/Infectious Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. Electronic address: namissah@noguchi.ug.edu.gh., Chlebowicz MA; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Ablordey A; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Tetteh CS; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Prah I; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., van der Werf TS; Department of Internal Medicine/Infectious Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Friedrich AW; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van Dijl JM; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Stienstra Y; Department of Internal Medicine/Infectious Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Rossen JW; Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jazyk: angličtina
Zdroj: International journal of medical microbiology : IJMM [Int J Med Microbiol] 2017 Jun; Vol. 307 (4-5), pp. 223-232. Date of Electronic Publication: 2017 Apr 19.
DOI: 10.1016/j.ijmm.2017.04.002
Abstrakt: Buruli ulcer (BU) is a necrotizing infection of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. BU wounds may also be colonized with other microorganisms including Staphylococcus aureus. This study aimed to characterize the virulence factors of S. aureus isolated from BU patients. Previously sequenced genomes of 21 S. aureus isolates from BU patients were screened for the presence of virulence genes. The results show that all S. aureus isolates harbored on their core genomes genes for known virulence factors like α-hemolysin, and the α- and β-phenol soluble modulins. Besides the core genome virulence genes, mobile genetic elements (MGEs), i.e. prophages, genomic islands, pathogenicity islands and a Staphylococcal cassette chromosome (SCC) were found to carry different combinations of virulence factors, among them genes that are known to encode factors that promote immune evasion, superantigens and Panton-Valentine Leucocidin. The present observations imply that the S. aureus isolates from BU patients harbor a diverse repertoire of virulence genes that may enhance bacterial survival and persistence in the wound environment and potentially contribute to delayed wound healing.
(Copyright © 2017 The Authors. Published by Elsevier GmbH.. All rights reserved.)
Databáze: MEDLINE
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