Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction.

Autor:	Pajtás D; Department of Organic Chemistry, University of Debrecen , Egyetem tér 1, H-4032 Debrecen, Hungary., Kónya K; Department of Organic Chemistry, University of Debrecen , Egyetem tér 1, H-4032 Debrecen, Hungary., Kiss-Szikszai A; Department of Organic Chemistry, University of Debrecen , Egyetem tér 1, H-4032 Debrecen, Hungary., Džubák P; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc , Hnevotinska 5, 779 00 Olomouc, Czech Republic., Pethő Z; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Nagyerdei krt. 98, H-4032 Debrecen, Hungary., Varga Z; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Nagyerdei krt. 98, H-4032 Debrecen, Hungary., Panyi G; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen , Nagyerdei krt. 98, H-4032 Debrecen, Hungary., Patonay T; Department of Organic Chemistry, University of Debrecen , Egyetem tér 1, H-4032 Debrecen, Hungary.
Jazyk:	angličtina
Zdroj:	The Journal of organic chemistry [J Org Chem] 2017 May 05; Vol. 82 (9), pp. 4578-4587. Date of Electronic Publication: 2017 Apr 25.
DOI:	10.1021/acs.joc.7b00124
Abstrakt:	The article describes the development of Buchwald-Hartwig amination of different bromoflavones with amino acid and peptide derivatives as nitrogen source giving unique structures. The previously observed racemization, which occurred during the synthesis of flavone-amino acid hybrids, was successfully prevented in most cases. The biological assays of these novel structures showed cytotoxic effects on different cancer cell lines.
Databáze:	MEDLINE
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