| Autor: |
Evans LE; Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research, London SW7 3RP, UK. matthew.cheeseman@icr.ac.uk., Jones K; Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research, London SW7 3RP, UK. matthew.cheeseman@icr.ac.uk., Cheeseman MD; Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research, London SW7 3RP, UK. matthew.cheeseman@icr.ac.uk. |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 May 04; Vol. 53 (37), pp. 5167-5170. |
| DOI: |
10.1039/c7cc01376k |
| Abstrakt: |
Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we designed a high-affinity non-nucleotide fluorescence polarisation probe. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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