| Autor: |
Sarkar U; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Hillebrand R; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Johnson KM; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Cummings AH; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Phung NL; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Rajapakse A; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Zhou H; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Willis JR; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Barnes CL; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211., Gates KS; University of Missouri, Department of Chemistry, 125 Chemistry Building, Columbia, MO 65211.; University of Missouri, Department of Biochemistry, 125 Chemistry Building, Columbia, MO 65211. |
| Abstrakt: |
Many 1,2,4-benzotriazine 1,4-dioxides display the ability to selectively kill the oxygen-poor cells found in solid tumors. As a result, there is a desire for synthetic routes that afford access to substituted 1,2,4-benzotriazine 1-oxides that can be used as direct precursors in the synthesis of 1,2,4-benzotriazine 1,4-dioxides. Here we describe the use of Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions for the construction of various 1,2,4-benzotriazine 1-oxide analogs bearing substituents at the 3-, 6-, and 7-positions. |
