Medial Entorhinal Cortex Selectively Supports Temporal Coding by Hippocampal Neurons.

Autor:	Robinson NTM; Center for Memory and Brain, Boston University, Boston, MA 02215, USA; Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK., Priestley JB; Center for Memory and Brain, Boston University, Boston, MA 02215, USA; Department of Neuroscience, Columbia University, New York, NY 10032, USA; Doctoral Program in Neurobiology and Behavior, Columbia University, New York, NY 10032, USA., Rueckemann JW; Center for Memory and Brain, Boston University, Boston, MA 02215, USA; Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA., Garcia AD; Center for Memory and Brain, Boston University, Boston, MA 02215, USA; Graduate Program in Neuroscience, University of Washington, Seattle, WA 98195, USA., Smeglin VA; Center for Memory and Brain, Boston University, Boston, MA 02215, USA., Marino FA; Center for Memory and Brain, Boston University, Boston, MA 02215, USA., Eichenbaum H; Center for Memory and Brain, Boston University, Boston, MA 02215, USA. Electronic address: hbe@bu.edu.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2017 May 03; Vol. 94 (3), pp. 677-688.e6. Date of Electronic Publication: 2017 Apr 20.
DOI:	10.1016/j.neuron.2017.04.003
Abstrakt:	Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inactivation of the medial entorhinal cortex on temporal, as well as spatial and object, coding by hippocampal CA1 neurons. Medial entorhinal inactivation produced a specific deficit in temporal coding in CA1 and resulted in significant impairment in memory across a temporal delay. In striking contrast, spatial and object coding remained intact. Further, we extended the scope of hippocampal phase precession to include object information relevant to memory and behavior. Overall, our work demonstrates that medial entorhinal activity plays an especially important role for CA1 in temporal coding and memory across time. (Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu