Evaluation of Se-phenyl-thiazolidine-4-carboselenoate protective activity against oxidative and behavioral stress in the maniac model induced by ouabain in male rats.

Autor: Sousa FSS; Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Programa de Pós Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Seus N; Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Programa de Pós Graduação em Química, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Alves D; Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Programa de Pós Graduação em Química, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Salles HD; Instituto de Química, Universidade Federal do Rio Grande do Sul, UFRGS, C.P. 15003, 91501-970, Porto Alegre, RS, Brazil., Schneider PH; Instituto de Química, Universidade Federal do Rio Grande do Sul, UFRGS, C.P. 15003, 91501-970, Porto Alegre, RS, Brazil., Savegnago L; Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Programa de Pós Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Pelotas, RS, Brazil; Centro de Desenvolvimento Tecnológico (CDtec), Programa de Pós Graduação em Biotecnologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil. Electronic address: luciellisavegnago@yahoo.com.br., Castro M; Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Programa de Pós Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2017 Jun 09; Vol. 651, pp. 182-187. Date of Electronic Publication: 2017 Apr 19.
DOI: 10.1016/j.neulet.2017.04.030
Abstrakt: This study investigates Se-phenyl-thiazolidine-4-carboselenoate (Se-PTC) protective activity against oxidative and behavioral stress in the model of mania induced by ouabain (OUA) in male rats. The compound used was Se-PTC (50mg/kg) and the positive control LiCl (45mg/kg) was administered for intragastric route (i.g.) 30min prior to administration of OUA (10 -5 M). OUA was dissolved in artificial cerebrospinal fluid (aCSF) and administered at the 5μl through an intracerebroventricular (i.c.v) cannula. The pretreatment with Se-PTC was effective in preventing the increase in locomotor activity induced by OUA, however the positive control LiCl is capable to block crossing augmentation induced by OUA. Na + /K + -ATPase activity was significantly reduced in OUA group and the Se-PTC to normalize Na +/ K +- ATPase activity. Pretreatment with Se-PTC protect against the increase in catalase activity and thiobarbituric acid reactive species (TBARS) content in the brain caused by OUA. Therefore, Se-PTC is effective against OUA-induced hyperactivity and alterations in brain oxidative status of rats.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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