Screening of Some Dioxaboreninopyridine and Aniline Derivatives for Carcinogenic Properties Using a Model Cell-Free System of Regenerating Rat Liver.

Autor: Syatkin SP; Peoples' Friendship University of Russia, Moscow, Russia. syata@mail.ru., Kirichuk AA; Peoples' Friendship University of Russia, Moscow, Russia., Soldatenkov AT; Peoples' Friendship University of Russia, Moscow, Russia., Kutyakov SV; Peoples' Friendship University of Russia, Moscow, Russia., Neborak EV; Peoples' Friendship University of Russia, Moscow, Russia., Shevkun NA; Peoples' Friendship University of Russia, Moscow, Russia., Kuznetsova OM; Peoples' Friendship University of Russia, Moscow, Russia., Skorik AS; Peoples' Friendship University of Russia, Moscow, Russia., Terent'ev AA; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Apr; Vol. 162 (6), pp. 801-807. Date of Electronic Publication: 2017 Apr 21.
DOI: 10.1007/s10517-017-3717-y
Abstrakt: We studied the effects of some aniline and dioxaborininopyridine derivatives on the rate of oxidative deamination of putrescine and polyamines in a tissue with high mitotic index. These effects were evaluated quantitatively by measuring diamine oxidase and polyamine oxidase activities in a model cell-free test system of regenerating rat liver tissue. Aniline derivatives exhibited mainly antiproliferative effects and promoted oxidative degradation of putrescine, spermidine, and spermine. Dioxaborininopyridine derivatives inhibited this process, thus exhibiting carcinogenic properties.
Databáze: MEDLINE
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