Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens.

Autor: Kim YG; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. gabriel.nunez@umich.edu yungikim77@gmail.com.; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Sakamoto K; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Seo SU; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Pickard JM; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Gillilland MG 3rd; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Pudlo NA; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Hoostal M; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Li X; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Wang TD; Departments of Biomedical Engineering and Mechanical Engineering, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Feehley T; Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Stefka AT; Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Schmidt TM; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Martens EC; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Fukuda S; Institute for Advanced Biosciences, Keio University, Yamagata, Japan.; PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan., Inohara N; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Nagler CR; Department of Pathology and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA., Núñez G; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. gabriel.nunez@umich.edu yungikim77@gmail.com.; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2017 Apr 21; Vol. 356 (6335), pp. 315-319.
DOI: 10.1126/science.aag2029
Abstrakt: The high susceptibility of neonates to infections has been assumed to be due to immaturity of the immune system, but the mechanism remains unclear. By colonizing adult germ-free mice with the cecal contents of neonatal and adult mice, we show that the neonatal microbiota is unable to prevent colonization by two bacterial pathogens that cause mortality in neonates. The lack of colonization resistance occurred when Clostridiales were absent in the neonatal microbiota. Administration of Clostridiales, but not Bacteroidales, protected neonatal mice from pathogen infection and abrogated intestinal pathology upon pathogen challenge. Depletion of Clostridiales also abolished colonization resistance in adult mice. The neonatal bacteria enhanced the ability of protective Clostridiales to colonize the gut.
(Copyright © 2017, American Association for the Advancement of Science.)
Databáze: MEDLINE
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