Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy.

Autor:	Min-Wen JC; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore; Stem Cell & Regenerative Biology, Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Yan-Jiang BC; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore; Stem Cell & Regenerative Biology, Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore., Mishra S; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Dai X; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Magae J; Magae Bioscience Institute, Tsukuba, Japan., Shyh-Chang N; Stem Cell & Regenerative Biology, Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. Electronic address: ngsc1@gis.a-star.edu.sg., Kumar AP; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore; Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA, Australia; National University Cancer Institute, National University Health System, Singapore, Singapore; University of North Texas, Denton, TX, United States. Electronic address: phcapk@nus.edu.sg., Sethi G; Magae Bioscience Institute, Tsukuba, Japan; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia. Electronic address: phcgs@nus.edu.sg.
Jazyk:	angličtina
Zdroj:	Advances in protein chemistry and structural biology [Adv Protein Chem Struct Biol] 2017; Vol. 108, pp. 199-225. Date of Electronic Publication: 2017 Feb 15.
DOI:	10.1016/bs.apcsb.2017.01.001
Abstrakt:	Cancer is an extremely complex disease comprising of a multitude of characteristic hallmarks that continue to evolve with time. At the genomic level, random mutations leading to deregulation of diverse oncogenic signal transduction cascades and polymorphisms coupled with environmental as well as life style-related factors are major causative agent contributing to chemoresistance and the failure of conventional therapies as well as molecular targeted agents. Hence, there is an urgent need to identify novel alternative therapies based on alternative medicines to combat this dreaded disease. Ascochlorin (ASC), an isoprenoid antibiotic isolated initially from the fermented broth of Ascochyta viciae, and its synthetic derivatives have recently demonstrated substantial antineoplastic effects in a variety of tumor cell lines and mouse models. The major focus of this review article is to briefly analyze the chemopreventive as well as therapeutic properties of ASC and its derivatives and to identify the multiple molecular targets modulated by this novel class of anticancer agent. (© 2017 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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