| Autor: |
Cleutjens FAHM; Department of Research and Education, Centre of Expertise for Chronic Organ Failure (CIRO)Horn, Netherlands., Ponds RWHM; Department of Medical Psychology, Maastricht UMC+/School for Mental Health and Neurosciences (MHeNS)Maastricht, Netherlands., Spruit MA; Department of Research and Education, Centre of Expertise for Chronic Organ Failure (CIRO)Horn, Netherlands.; Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht, Netherlands., Burgmans S; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht UniversityMaastricht, Netherlands., Jacobs HIL; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht UniversityMaastricht, Netherlands., Gronenschild EHBM; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht UniversityMaastricht, Netherlands., Staals J; Department of Neurology, Maastricht University Medical CentreMaastricht, Netherlands., Franssen FME; Department of Research and Education, Centre of Expertise for Chronic Organ Failure (CIRO)Horn, Netherlands., Dijkstra JB; Department of Medical Psychology, Maastricht UMC+/School for Mental Health and Neurosciences (MHeNS)Maastricht, Netherlands., Vanfleteren LEGW; Department of Research and Education, Centre of Expertise for Chronic Organ Failure (CIRO)Horn, Netherlands., Hofman PA; Department of Radiology, Maastricht University Medical CentreMaastricht, Netherlands., Wouters EFM; Department of Research and Education, Centre of Expertise for Chronic Organ Failure (CIRO)Horn, Netherlands.; Department of Respiratory Medicine, Maastricht UMC+Maastricht, Netherlands., Janssen DJA; Department of Research and Education, Centre of Expertise for Chronic Organ Failure (CIRO)Horn, Netherlands. |
| Abstrakt: |
The neural correlates of cognitive impairment in chronic obstructive pulmonary disease (COPD) are not yet understood. Structural brain abnormalities could possibly be associated with the presence of cognitive impairment through cigarette smoke, inflammation, vascular disease, or hypoxemia in these patients. This study aimed to investigate whether macrostructural brain magnetic resonance imaging (MRI) features of cerebral small vessel disease (SVD) and hippocampal volume (HCV) are related to cognitive performance in patients with COPD. A subgroup of cognitively high and low-performing COPD patients of the COgnitive-PD study, underwent a brain 3T MRI. SVD as a marker of vascular damage was assessed using qualitative visual rating scales. HCV as a marker of neurodegeneration was assessed using the learning embedding for atlas propagation (LEAP) method. Features of SVD and HCV were compared between cognitively high and low-performing individuals using Mann Whitney U tests and independent samples t -tests, respectively. No group differences were reported between 25 high-performing (mean age 60.3 (standard deviation [SD] 9.7) years; 40.0% men; forced expiratory volume in first second [FEV 1 ] 50.1% predicted) and 30 low-performing patients with COPD (mean age 60.6 (SD 6.8) years; 53.3% men; FEV 1 55.6% predicted) regarding demographics, clinical characteristics, comorbidities and the presence of the SVD features and HCV. To conclude , the current study does not provide evidence for a relationship between cerebral SVD and HCV and cognitive functioning in patients with COPD. Additional studies will be needed to determine other possible mechanisms of cognitive impairment in patients with COPD, including microstructural brain changes and inflammatory-, hormonal-, metabolic- and (epi)genetic factors. |
