| Autor: |
Perfilova VN; Volgograd State Medical University, Russian Federation; vnperfilova@mail.ru., Sadikova NV; Volgograd State Medical University, Russian Federation., Prokofiev II; Volgograd State Medical University, Russian Federation., Inozemtsev OV; Volgograd State Medical University, Russian Federation., Tyurenkov IN; Volgograd State Medical University, Russian Federation. |
| Jazyk: |
ruština |
| Zdroj: |
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2016; Vol. 29 (1), pp. 116-122. |
| Abstrakt: |
The effect of the 24-hour immobilization-painful stress on myocardial contractility of young (6-month), middle-aged (12-month) and old (24-month) female rats was studied. It was identified a reduction of the functional reserve of the heart, which showed a smaller growth rates of contraction and relaxation of the myocardium (+ dP/dt max and -dP/dt max), left ventricular pressure (LVP) and the maximum intensity of the functioning of the structures (MIFS) under increased pre- afterload and adrenergic stimulation of the heart, especially pronounced in the group of 24-month old rats. The animals of all ages treated before and after stressing glufimet in a dose 29 mg/kg, have higher rates of growth + dP/dt max, -dP/dt max, LVP and MIFS during load tests, most significant rates of growth are noticed in older rats compared with the young and middle-aged. Phenibut improves studied parameters equally at 6, 12 and 24-month old females, subjected to stress. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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