Inhibition of P-glycoprotein stimulates cell death under Hypoxia-mimicking conditions.
| Autor: | Vdovin AS; M.V. Lomonosov Moscow State University, Moscow, Russia.; National Research Center for Hematology, Russian Federation Ministry of Healthcare, Moscow, Russia., Maximchik PV; M.V. Lomonosov Moscow State University, Moscow, Russia., Kulikov AV; M.V. Lomonosov Moscow State University, Moscow, Russia., Zhivotovsky BD; M.V. Lomonosov Moscow State University, Moscow, Russia. boris.zhivotovsky@ki.se.; Karolinska Institutet, Solna, Sweden. boris.zhivotovsky@ki.se., Gogvadze VG; M.V. Lomonosov Moscow State University, Moscow, Russia.; Karolinska Institutet, Solna, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2017 Jan; Vol. 472 (1), pp. 27-30. Date of Electronic Publication: 2017 Apr 19. |
| DOI: | 10.1134/S1607672917010100 |
| Abstrakt: | The most common drug resistance mechanism in tumor cells is expression on their surface of the energy-dependent pump like P-glycoprotein (P-gp) that expels chemotherapeutic agents from the interior. An imitation of the hypoxic condition by the iron chelator deferoxamine caused Hypoxia-inducible factor 1-alpha (HIF-1α) stabilization and inhibition of doxorubicin-induced apoptosis in colon cancer НСТ116 cells. P-gp blocker verapamil suppressed doxorubicin accumulation leading to cell death induction. Considering these results, P-gp may be used as a potential target to stimulate chemotherapeutic drugs activity that will contribute to more efficient tumor cells elimination. |
| Databáze: | MEDLINE |
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