| Autor: |
Tasca KI; Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Caleffi JT; Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Correa CR; Department of Pathology, FMB, UNESP, Botucatu, SP, Brazil., Gatto M; Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Tavares FC; Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Camargo CC; Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Sartori A; Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Biasin M; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy., de Souza LDR; Department of Tropical Diseases, Botucatu Medical School (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil. |
| Abstrakt: |
Background . The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters. This is a longitudinal study including 30 asymptomatic patients divided according to their CD4+ T cell count (G1: <500 cell/mL; G2: >500 cell/mL) before (M0) and after (M1) cART initiation. We analyzed total antioxidant capacity (TAC), fat-soluble vitamins, malondialdehyde, 8-isoprostane, and DNA damage. Results . Results showed a decrease in TAC, retinol, α -tocopherol, and some carotenoids, in addition to a significant increase in DNA damage at M1. These changes were more evident in G2 subjects. Moreover, there was a significant 8-isoprostane increase at M1 in individuals belonging to G1. Conclusion . The results indicate that cART interfered in the redox system, mainly by reducing the antioxidant defenses. In addition, patients who had CD4+ T counts higher than 500 cells/mm 3 showed more susceptibility to genotoxicity, while patients with less CD4+ T counts displayed more damage triggered by lipoperoxidation. Considering the early beginning of cART, its chronic use, and its capacity to alter the redox status, further long-term studies on larger cohorts are needed to define the best time to initiate therapy and to investigate new strategies to delay the development of non-AIDS diseases. |
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