Dual-Genotype Diffuse Low-Grade Glioma: Is It Really Time to Abandon Oligoastrocytoma As a Distinct Entity?

Autor:	Barresi V; From the Department of Human Pathology, University of Messina, Messina, Italy (VB and SL); Department of Pathology, Treviso General Hospital, Treviso, Italy (LV, GG and SR); and Department of Neurosciences, University of Messina, Messina, Italy (MC)., Lionti S; From the Department of Human Pathology, University of Messina, Messina, Italy (VB and SL); Department of Pathology, Treviso General Hospital, Treviso, Italy (LV, GG and SR); and Department of Neurosciences, University of Messina, Messina, Italy (MC)., Valori L; From the Department of Human Pathology, University of Messina, Messina, Italy (VB and SL); Department of Pathology, Treviso General Hospital, Treviso, Italy (LV, GG and SR); and Department of Neurosciences, University of Messina, Messina, Italy (MC)., Gallina G; From the Department of Human Pathology, University of Messina, Messina, Italy (VB and SL); Department of Pathology, Treviso General Hospital, Treviso, Italy (LV, GG and SR); and Department of Neurosciences, University of Messina, Messina, Italy (MC)., Caffo M; From the Department of Human Pathology, University of Messina, Messina, Italy (VB and SL); Department of Pathology, Treviso General Hospital, Treviso, Italy (LV, GG and SR); and Department of Neurosciences, University of Messina, Messina, Italy (MC)., Rossi S; From the Department of Human Pathology, University of Messina, Messina, Italy (VB and SL); Department of Pathology, Treviso General Hospital, Treviso, Italy (LV, GG and SR); and Department of Neurosciences, University of Messina, Messina, Italy (MC).
Jazyk:	angličtina
Zdroj:	Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2017 May 01; Vol. 76 (5), pp. 342-346.
DOI:	10.1093/jnen/nlx024
Abstrakt:	We report a unique case of dual-genotype oligoastrocytoma characterized by IDH2 gene mutation. The tumor was resected from the temporal lobe of a 25-year-old man. At histological examination with hematoxylin and eosin stain, it showed distinct oligodendroglial and astrocytic areas. The former retained alpha-thalassaemia/mental retardation X-linked (ATRX) immuno-expression and had absent staining for p53, while the latter had ATRX loss and p53 over-expression. Molecular analyses were separately assessed in the 2 tumor components. Gene sequencing disclosed IDH2 mutation in both, whereas oligodendroglial, but not astrocytic areas, had 1p/19q codeletion and telomerase reverse transcriptase promoter mutation. Distinction of dual-genotype oligoastrocytoma from oligodendroglioma and astrocytoma might be clinically relevant for prognosis and therapy. Because most studies that investigated the molecular phenotype of oligoastrocytomas have focused on IDH1 R132H mutated cases, we suggest further analyses on diffuse gliomas with heterogeneous (astrocytic and oligodendroglial) morphology before oligoastrocytoma is dismissed as a distinct nosological entity. (© 2017 American Association of Neuropathologists, Inc. All rights reserved.)
Databáze:	MEDLINE
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