Chromosome analysis in a case of a plutonium contaminated wound.
| Autor: | Tawn EJ; Centre for Integrated Genomic Medical Research (CIGMR), Centre for Epidemiology, Institute of Population Health, The University of Manchester, Manchester, M13 9PT, United Kingdom. Westlakes Research Institute, Westlakes Science and Technology Park, Moor Row, Cumbria, CA24 3LN, United Kingdom., Curwen GB, Riddell AE, Lloyd DC, Ainsbury EA |
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| Jazyk: | angličtina |
| Zdroj: | Journal of radiological protection : official journal of the Society for Radiological Protection [J Radiol Prot] 2017 Jun 26; Vol. 37 (2), pp. N13-N19. Date of Electronic Publication: 2017 Apr 18. |
| DOI: | 10.1088/1361-6498/aa595c |
| Abstrakt: | Chromosome analysis of peripheral blood lymphocytes was undertaken over a 10 year period following an intake of plutonium through a hand wound. Frequencies of cells with unstable complex aberrations remained high throughout this time, probably reflecting direct exposure of lymphocytes as they passed plutonium which had transferred to regional lymph nodes. Analysis at the final sampling time also revealed cells with stable aberrations at a much higher frequency relative to the number of unstable cells than expected from direct exposure, and is therefore most likely to be reflecting exposure to lymphocyte precursor cells from plutonium that has become deposited on bone surfaces. |
| Databáze: | MEDLINE |
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