Reduced dose CT with model-based iterative reconstruction compared to standard dose CT of the chest, abdomen, and pelvis in oncology patients: intra-individual comparison study on image quality and lesion conspicuity.

Autor: Morimoto LN; Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, 300 Pasteur Drive, Room H1307, Stanford, CA, 94305-5621, USA., Kamaya A; Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, 300 Pasteur Drive, Room H1307, Stanford, CA, 94305-5621, USA., Boulay-Coletta I; Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, 300 Pasteur Drive, Room H1307, Stanford, CA, 94305-5621, USA.; Department of Radiology, Fondation Hôpital Saint-Joseph, Paris, France., Fleischmann D; Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, 300 Pasteur Drive, Room H1307, Stanford, CA, 94305-5621, USA., Molvin L; Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, 300 Pasteur Drive, Room H1307, Stanford, CA, 94305-5621, USA., Tian L; Department of Health, Research & Policy, Stanford University, Stanford, CA, USA., Fisher G; Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA., Wang J; Department of Environmental Health and Safety, Stanford University, Stanford, CA, USA., Willmann JK; Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, 300 Pasteur Drive, Room H1307, Stanford, CA, 94305-5621, USA. willmann@stanford.edu.
Jazyk: angličtina
Zdroj: Abdominal radiology (New York) [Abdom Radiol (NY)] 2017 Sep; Vol. 42 (9), pp. 2279-2288.
DOI: 10.1007/s00261-017-1140-5
Abstrakt: Purpose: To compare image quality and lesion conspicuity of reduced dose (RD) CT with model-based iterative reconstruction (MBIR) compared to standard dose (SD) CT in patients undergoing oncological follow-up imaging.
Methods: Forty-four cancer patients who had a staging SD CT within 12 months were prospectively included to undergo a weight-based RD CT with MBIR. Radiation dose was recorded and tissue attenuation and image noise of four tissue types were measured. Reproducibility of target lesion size measurements of up to 5 target lesions per patient were analyzed. Subjective image quality was evaluated for three readers independently utilizing 4- or 5-point Likert scales.
Results: Median radiation dose reduction was 46% using RD CT (P < 0.01). Median image noise across all measured tissue types was lower (P < 0.01) in RD CT. Subjective image quality for RD CT was higher (P < 0.01) in regard to image noise and overall image quality; however, there was no statistically significant difference regarding image sharpness (P = 0.59). There were subjectively more artifacts on RD CT (P < 0.01). Lesion conspicuity was subjectively better in RD CT (P < 0.01). Repeated target lesion size measurements were highly reproducible both on SD CT (ICC = 0.987) and RD CT (ICC = 0.97).
Conclusions: RD CT imaging with MBIR provides diagnostic imaging quality and comparable lesion conspicuity on follow-up exams while allowing dose reduction by a median of 46% compared to SD CT imaging.
Databáze: MEDLINE
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