New insights into the toxicity of mineral fibres: A combined in situ synchrotron μ-XRD and HR-TEM study of chrysotile, crocidolite, and erionite fibres found in the tissues of Sprague-Dawley rats.

Autor: Gualtieri AF; Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, I-41125 Modena, Italy. Electronic address: alessandro.gualtieri@unimore.it., Bursi Gandolfi N; Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, I-41125 Modena, Italy., Pollastri S; Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via Campi 103, I-41125 Modena, Italy., Burghammer M; ESRF, 71 Avenue de Martyrs, F-38000 Grenoble, France., Tibaldi E; Cancer Research Centre, European Ramazzini Institute, Castello di Bentivoglio, Via Saliceto 3, I-40010 Bentivoglio, Bologna, Italy., Belpoggi F; Cancer Research Centre, European Ramazzini Institute, Castello di Bentivoglio, Via Saliceto 3, I-40010 Bentivoglio, Bologna, Italy., Pollok K; Institut für Geowissenschaften Mineralogie, Friedrich-Schiller-Universität Jena, Carl-Zeiss-Promenade 10, D-07745 Jena, Germany., Langenhorst F; Institut für Geowissenschaften Mineralogie, Friedrich-Schiller-Universität Jena, Carl-Zeiss-Promenade 10, D-07745 Jena, Germany., Vigliaturo R; Laboratory for Material Chemistry, National Institute of Chemistry, Hajdrihova 19, Ljubljana, Slovenia., Dražić G; Laboratory for Material Chemistry, National Institute of Chemistry, Hajdrihova 19, Ljubljana, Slovenia.
Jazyk: angličtina
Zdroj: Toxicology letters [Toxicol Lett] 2017 May 15; Vol. 274, pp. 20-30. Date of Electronic Publication: 2017 Apr 12.
DOI: 10.1016/j.toxlet.2017.04.004
Abstrakt: Along the line of the recent research topic aimed at understanding the in vivo activity of mineral fibres and their mechanisms of toxicity, this work describes the morpho-chemical characteristics of the mineral fibres found in the tissues of Sprague-Dawley rats subjected to intraperitoneal/intrapleural injection of UICC chrysotile, UICC crocidolite and erionite-Na from Nevada (USA). The fibres are studied with in situ synchrotron powder diffraction and high resolution transmission electron microscopy to improve our understanding of the mechanisms of toxicity of these mineral fibres. In contact with the tissues of the rats, chrysotile fibres are prone to dissolve, with leaching of Mg and production of a silica rich relict. On the other hand, crocidolite and erionite-Na fibres are stable even for very long contact times within the tissues of the rats, showing just a thin dissolution amorphous halo. These findings support the model of a lower biopersistence of chrysotile with respect to crocidolite and erionite-Na but the formation of a silica-rich fibrous residue after the pseudo-amorphization of chrysotile may justify a higher cytotoxic potential and intense inflammatory activity of chrysotile in the short term in contact with the lung tissues.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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