Late-Onset Alzheimer Disease.
| Autor: | Pierce AL; Department of Neurology and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1100 Medical Plaza Drive, Irvine, CA 92697, USA. Electronic address: piercea@uci.edu., Bullain SS; Department of Neurology and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1515 Hewitt Hall, Irvine, CA 92697, USA., Kawas CH; Departments of Neurology, Neurobiology & Behavior, Epidemiology, and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1121 Gillespie, Irvine, CA 92697, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Neurologic clinics [Neurol Clin] 2017 May; Vol. 35 (2), pp. 283-293. |
| DOI: | 10.1016/j.ncl.2017.01.006 |
| Abstrakt: | The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease. (Copyright © 2017 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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