| Autor: |
Cevallos VM; 1 Center for Translational Research, Universidad de Las Américas, Quito, Ecuador., Díaz V; 2 Secretariat of the Environment, Municipality of the Quito Metropolitan District, Quito, Ecuador.; 3 School of Medicine, College of Health Sciences, Universidad de Las Américas, Quito, Ecuador., Sirois CM; 1 Center for Translational Research, Universidad de Las Américas, Quito, Ecuador.; 3 School of Medicine, College of Health Sciences, Universidad de Las Américas, Quito, Ecuador.; 4 Center for Biomedical Research, Eugenio Espejo College of Health Sciences, Universidad Tecnológica Equinoccial, Quito, Ecuador. |
| Abstrakt: |
Automobile traffic, industrial processes and natural phenomena cause notable air pollution, including gaseous and particulate contaminants, in urban centers. Exposure to particulate matter (PM) air pollution affects human health, and has been linked to respiratory, cardiovascular and neurological diseases. The mechanisms underlying inflammation in these diverse diseases, and to what extent health effects are different for PM obtained from different sources or locations, are still unclear. This study investigated the in vitro toxicity of ambient course (PM 10 ) and fine (PM 2.5 ) particulate matter collected at seven sites in the urban and periurban zones of Quito, Ecuador. Material from all sites was capable of activating TLR2 and TLR4 signaling pathways, with differences in the activation related to particle size. Additionally, airborne particulate matter from Quito is an effective activator of the NLRP3 inflammasome. |
