| Autor: |
Ward PA; University of Michigan Medical School, Department of Pathology, Ann Arbor 48109., Cunningham TW, Walker BA, Johnson KJ |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1988 Jul 29; Vol. 154 (2), pp. 746-51. |
| DOI: |
10.1016/0006-291x(88)90203-3 |
| Abstrakt: |
In formyl peptide stimulated human neutrophils the enhancement of O2.- responses by ATP and ATP S requires extracellular calcium. In contrast, the inhibitory effects of adenosine are independent of a calcium requirement. Rates of O2.- generation are not affected by these adenine compounds. Rather, ATP and ATP S cause a sustained period of generation whereas adenosine causes an abrupt early termination of the O2- response. The differing calcium requirements for regulatory effects of adenine compounds on O2.- responses of stimulated neutrophils suggests that ATP (or ATP gamma S) and adenosine may exert their effects at different points in the pathway of signal transduction events. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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