Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction.

Autor:	Satilmisoglu MH; Department of Cardiology., Ozyilmaz SO; Department of Cardiology., Gul M; Department of Cardiology., Ak Yildirim H; Department of Biochemistry, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul., Kayapinar O; Department of Cardiology, Duzce University Faculty of Medicine, Duzce., Gokturk K; Department of Infectious Diseases., Aksu H; Department of Cardiology., Erkanli K; Department of Thoracic and Cardiovascular Surgery, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey., Eksik A; Department of Cardiology.
Jazyk:	angličtina
Zdroj:	Therapeutics and clinical risk management [Ther Clin Risk Manag] 2017 Mar 29; Vol. 13, pp. 393-400. Date of Electronic Publication: 2017 Mar 29 (Print Publication: 2017).
DOI:	10.2147/TCRM.S124794
Abstrakt:	Purpose: To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Patients and Methods: A total of 234 patients (mean age: 57.2±11.7 years, 75.2% were males) hospitalized with NSTEMI were included. Data on D-dimer assay, GRACE and TIMI risk scores were recorded. Logistic regression analysis was conducted to determine the risk factors predicting increased mortality. Results: Median D-dimer levels were 349.5 (48.0-7,210.0) ng/mL, the average TIMI score was 3.2±1.2 and the GRACE score was 90.4±27.6 with high GRACE scores (>118) in 17.5% of patients. The GRACE score was correlated positively with both the D-dimer assay ( r =0.215, P =0.01) and TIMI scores ( r =0.504, P =0.000). Multivariate logistic regression analysis revealed that higher creatinine levels (odds ratio =18.465, 95% confidence interval: 1.059-322.084, P =0.046) constituted the only significant predictor of increased mortality risk with no predictive values for age, D-dimer assay, ejection fraction, glucose, hemoglobin A1c, sodium, albumin or total cholesterol levels for mortality. Conclusion: Serum creatinine levels constituted the sole independent determinant of mortality risk, with no significant values for D-dimer assay, GRACE or TIMI scores for predicting the risk of mortality in NSTEMI patients. Competing Interests: Disclosure The authors report no conflicts of interest in this work.
Databáze:	MEDLINE
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