Epithelial-mesenchymal plasticity and circulating tumor cells: Travel companions to metastases.

Autor: Francart ME; GIGA-Cancer, Laboratory of Tumor and Development Biology, University of Liège, Liège, Belgium., Lambert J; GIGA-Cancer, Laboratory of Tumor and Development Biology, University of Liège, Liège, Belgium., Vanwynsberghe AM; GIGA-Cancer, Laboratory of Tumor and Development Biology, University of Liège, Liège, Belgium., Thompson EW; Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, and Translational Research Institute Brisbane, and University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, Australia., Bourcy M; GIGA-Cancer, Laboratory of Tumor and Development Biology, University of Liège, Liège, Belgium., Polette M; Inserm UMR-S 903, University of Reims Champagne-Ardenne, Biopathology Laboratory, CHU of Reims, Reims, France., Gilles C; GIGA-Cancer, Laboratory of Tumor and Development Biology, University of Liège, Liège, Belgium.
Jazyk: angličtina
Zdroj: Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2018 Mar; Vol. 247 (3), pp. 432-450. Date of Electronic Publication: 2017 May 26.
DOI: 10.1002/dvdy.24506
Abstrakt: Epithelial-mesenchymal transitions (EMTs) associated with metastatic progression may contribute to the generation of hybrid phenotypes capable of plasticity. This cellular plasticity would provide tumor cells with an increased potential to adapt to the different microenvironments encountered during metastatic spread. Understanding how EMT may functionally equip circulating tumor cells (CTCs) with an enhanced competence to survive in the bloodstream and niche in the colonized organs has thus become a major cancer research axis. We summarize here clinical data with CTC endpoints involving EMT. We then review the work functionally linking EMT programs to CTC biology and deciphering molecular EMT-driven mechanisms supporting their metastatic competence. Developmental Dynamics 247:432-450, 2018. © 2017 Wiley Periodicals, Inc.
(© 2017 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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