Influenza C in Lancaster, UK, in the winter of 2014-2015.

Autor:	Atkinson KV; Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancaster, LA1 4YT, UK.; Present address: University College London Hospitals NHS Foundation Trust, London, UK., Bishop LA; Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancaster, LA1 4YT, UK.; Royal Lancaster Infirmary, Ashton Road, Lancaster, LA1 4RP, UK., Rhodes G; Centre for Ecology & Hydrology, Lancaster Environment Centre, Lancaster University, Lancaster, LA1 4AP, UK., Salez N; UMR_D 190, Emergence des Pathologies Virales, Aix-Marseille University, 27 Bd Jean Moulin, Marseille cedex 05, 13005, France., McEwan NR; Institute of Biological, Environmental & Rural Sciences, Aberystwyth University, Aberystwyth, SY23 3DA, UK., Hegarty MJ; Institute of Biological, Environmental & Rural Sciences, Aberystwyth University, Aberystwyth, SY23 3DA, UK., Robey J; Queen Square Medical Practice, 2 Queen Square, Lancaster, LA1 1RP, UK., Harding N; Queen Square Medical Practice, 2 Queen Square, Lancaster, LA1 1RP, UK., Wetherell S; Queen Square Medical Practice, 2 Queen Square, Lancaster, LA1 1RP, UK., Lauder RM; Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancaster, LA1 4YT, UK., Pickup RW; Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancaster, LA1 4YT, UK.; Centre for Ecology & Hydrology, Lancaster Environment Centre, Lancaster University, Lancaster, LA1 4AP, UK., Wilkinson M; Royal Lancaster Infirmary, Ashton Road, Lancaster, LA1 4RP, UK., Gatherer D; Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancaster, LA1 4YT, UK. d.gatherer@lancaster.ac.uk.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2017 Apr 13; Vol. 7, pp. 46578. Date of Electronic Publication: 2017 Apr 13.
DOI:	10.1038/srep46578
Abstrakt:	Influenza C is not included in the annual seasonal influenza vaccine, and has historically been regarded as a minor respiratory pathogen. However, recent work has highlighted its potential role as a cause of pneumonia in infants. We performed nasopharyngeal or nasal swabbing and/or serum sampling (n = 148) in Lancaster, UK, over the winter of 2014-2015. Using enzyme-linked immunosorbent assay (ELISA), we obtain seropositivity of 77%. By contrast, only 2 individuals, both asymptomatic adults, were influenza C-positive by polymerase chain reaction (PCR). Deep sequencing of nasopharyngeal samples produced partial sequences for 4 genome segments in one of these patients. Bayesian phylogenetic analysis demonstrated that the influenza C genome from this individual is evolutionarily distant to those sampled in recent years and represents a novel genome constellation, indicating that it may be a product of a decades-old reassortment event. Although we find no evidence that influenza C was a significant respiratory pathogen during the winter of 2014-2015 in Lancaster, we confirm previous observations of seropositivity in the majority of the population. (170 words).
Databáze:	MEDLINE
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