NK cells control breast cancer and related cancer stem cell hematological spread.

Autor:	Tallerico R; Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro , Catanzaro, Italy., Conti L; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin , Turin, Italy., Lanzardo S; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin , Turin, Italy., Sottile R; Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy; Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Garofalo C; Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro , Catanzaro, Italy., Wagner AK; Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet , Stockholm, Sweden., Johansson MH; Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet , Stockholm, Sweden., Cristiani CM; Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro , Catanzaro, Italy., Kärre K; Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet , Stockholm, Sweden., Carbone E; Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy; Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Cavallo F; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin , Turin, Italy.
Jazyk:	angličtina
Zdroj:	Oncoimmunology [Oncoimmunology] 2017 Feb 23; Vol. 6 (3), pp. e1284718. Date of Electronic Publication: 2017 Feb 23 (Print Publication: 2017).
DOI:	10.1080/2162402X.2017.1284718
Abstrakt:	The growth and recurrence of a number of cancers is driven by a scarce population of cancer stem cells (CSCs), which are resistant to most current therapies. It has been shown previously that natural killer (NK) cells recognize human glioma, melanoma, colon and prostate CSCs in vitro . We herein show that human and mouse breast CSCs are also susceptible to NK cytotoxic activity in vitro . Moreover, CSC induced autologous NK cell activation and expansion in vivo , which correlate with the inhibition of CSC metastatic spread. These data suggest that NK cells control CSC metastatic spread in vivo and that their use in breast cancer therapy may well be fruitful.
Databáze:	MEDLINE
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