| Autor: |
Bogdanov A; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany., Hertzer C; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany., Kehraus S; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany., Nietzer S; Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl-von-Ossietzki University Oldenburg, Schleusenstraße 1, 26382 Wilhelmshaven, Germany., Rohde S; Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl-von-Ossietzki University Oldenburg, Schleusenstraße 1, 26382 Wilhelmshaven, Germany., Schupp PJ; Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl-von-Ossietzki University Oldenburg, Schleusenstraße 1, 26382 Wilhelmshaven, Germany., Wägele H; Zoologisches Forschungsmuseum Alexander Koenig, Adenauerallee 160, 53113 Bonn, Germany., König GM; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany. |
| Abstrakt: |
Phyllodesmium longicirrum is the largest aeolidoidean species known to date, and extremely rich in terpenoid chemistry. Herein we report the isolation of a total of 19 secondary metabolites from a single specimen of this species, i.e., steroids 1-4 , cembranoid diterpenes 5-13 , complex biscembranoids 14 and 15 , and the chatancin-type diterpenes 16-19 . These compounds resemble those from soft corals of the genus Sarcophyton , of which to date, however, only S. trocheliophorum is described as a food source for P. longicirrum . Fish feeding deterrent activity was determined using the tropical puffer fish Canthigaster solandri , and showed activity for (2 S )-isosarcophytoxide ( 10 ), cembranoid bisepoxide 12 and 4-oxochatancin ( 16 ). Determining the metabolome of P. longicirrum and its bioactivity, makes it evident that this seemingly vulnerable soft bodied animal is well protected from fish by its chemical arsenal. |
