Local application of statins in the treatment of experimental periodontal disease in rats.

Autor:	Santos BF; Universidade Federal de Alfenas, Faculdade de Odontologia, Alfenas, MG, Brasil., Souza EQ; Universidade Federal de Alfenas, Faculdade de Odontologia, Alfenas, MG, Brasil., Brigagão MR; Universidade Federal de Alfenas, Faculdade de Odontologia, Departamento de Bioquímica, Alfenas, MG, Brasil., Lima DC; Universidade Federal de Alfenas, Faculdade de Odontologia, Departamento de Clínica e Cirurgia, Alfenas, MG, Brasil., Fernandes LA; Universidade Federal de Alfenas, Faculdade de Odontologia, Departamento de Clínica e Cirurgia, Alfenas, MG, Brasil.
Jazyk:	angličtina
Zdroj:	Journal of applied oral science : revista FOB [J Appl Oral Sci] 2017 Mar-Apr; Vol. 25 (2), pp. 168-176.
DOI:	10.1590/1678-77572016-0149
Abstrakt:	Objective: The objective of this study was to evaluate the local effects of statins as adjuvants for treatment by scaling and root planing (SRP) of periodontal disease induced in rats. Material and Methods: Ninety rats were used in the present experiment. Periodontal disease was induced in all animals using a cotton thread placed in the left first mandibular molar. After 7 days of induction, the bandage was removed and the animals were divided into three groups: 1) NT group (n=30), no treatment; 2) SRP group (n=30): SRP and irrigation with control gel; 3) S group (n=30) - SRP and irrigation with Simvastatin. Ten animals from each group were euthanized at 7, 15 and 30 days after treatment. Gingival biopsy specimens were processed to analyze the expression of matrix metalloproteinase 8 (MMP-8). The mandibles were removed and submitted to radiographic and laboratory processing for histometric analysis. Results: The S group showed a significantly lower expression of MMP-8 compared to NT and SRP groups in all experimental periods. In the radiographic and histometric analyses between the groups, S group showed a significantly lower bone loss (BL) compared to NT and SRP groups in all experimental periods. Conclusions: Within the limits of this study, it can be concluded that locally applied statin was effective as an adjuvant treatment for SRP in rats with induced periodontal disease.
Databáze:	MEDLINE
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